Article: Novel Microparticles

Here’s a recent LOC article on combining multiple micro- techniques to produce structured microparticles:

Article citation: Ki Wan Bong, Lab Chip, 2009, DOI: 10.1039/b821930c

Lock

release lithography for 3D and composite microparticles

Ki Wan Bong, Daniel C. Pregibon and Patrick S. Doyle

We present a method called Lock Release Lithogr

aphy (LRL) that utilizes a combination of channel topography, mask design, and pressure-induced channel deformation to form and release particles in a cycled fashion. This technique provides a means for the high-throughput production of particles with complex 3D morphologies and composite particles with spatially configurable chemistries. In this work, we demonstrate a diverse set of functional particles including those displaying heterogeneous swelling characteristics and containing functional entities such as nucleic acids, proteins and beads.